Androgens

Methasterone

A potent steroid found in marketed supplements, with a human case series documenting severe cholestatic liver injury.

Human liver-injury case series plus product-analysis investigation; evidence checked 2026-10-01

Also known as: Methasteron · Superdrol

Methasterone molecular structure — Structure reference · C21H34O2

Practical use

Evidence interpretation and concrete review questions

Act on jaundice or dark urine: Seek medical assessment rather than waiting for a supplement to clear.
Include recently stopped products: The chronology can extend beyond the last use.
Preserve lot information: It may help distinguish known ingredients from contamination or mislabeling.

Five cases of cholestatic liver injury

PubChem chemical identity; checked October 1, 2026

Additional primary or official source

Overview

Methasterone, also spelled methasteron, is a dimethylated androgen often associated with the name Superdrol. Chemical analysis has found it in products marketed as vitamins as well as in steroid-oriented products; the packaging category is not proof of contents.

Risks and limitations

In a five-case series, jaundice began after exposure had already ended and bilirubin continued to rise before recovery. Stopping exposure does not guarantee that an evolving injury has peaked.

How to read this

Clinical cases establish a credible hazard, while product testing helps explain why unsuspected exposure can occur.

Research explained

Five cases of cholestatic liver injury

Who was studied

Five previously healthy patients with methasteron exposure assessed at tertiary-care centers.

What was found

Jaundice appeared after discontinuation; bilirubin peaked later. All five ultimately recovered without identified residual hepatic dysfunction in the report.