Androgens
Dimethandrolone
An investigational androgen/progestogen whose undecanoate prodrug has short human studies in male-contraceptive development.
Short placebo-controlled human trials; exploratory metabolic comparison; evidence checked 2026-10-01
Also known as: DMA
Practical use
Evidence interpretation and concrete review questions
- Name the formulation
- Separate DMA from DMAU in any clinical claim.
- Ask for the contraceptive outcome
- Look for sperm and pregnancy outcomes rather than hormone values alone.
- Keep follow-up visible
- Recovery and longer-term tolerability need their own evidence.
Metabolic findings in two prototype trials
Overview
Dimethandrolone is the active steroid; dimethandrolone undecanoate, or DMAU, is a prodrug studied in people. Combined androgenic and progestational actions are being investigated for suppression of reproductive hormone signaling. A contraceptive prototype is not established contraception.
Risks and limitations
Short trials found lower HDL and SHBG with higher weight and hematocrit. An unchanged fasting-glucose result does not make those other effects disappear or establish long-term metabolic safety.
How to read this
The critical contraceptive question is reliable pregnancy prevention with acceptable recovery and adverse effects, not hormone suppression alone.
Research explained
Metabolic findings in two prototype trials
Who was studied
Stored samples from separate 28-day trials of DMAU and another investigational progestational androgen in healthy men.
What was found
Both groups showed lower HDL/SHBG and higher weight/hematocrit. Neither showed significant changes in fasting glucose, insulin or HOMA-IR; some other changes differed between compounds.
What it cannot establish
This was a comparison across two short trials, not a long-term head-to-head contraceptive-efficacy trial.
Read the original studyState parent versus prodrug
The human exposure studied was DMAU, so those findings should retain the undecanoate name.
Supporting sourceAcceptability is another endpoint
A companion trial report examined whether participants found the prototype acceptable; that does not measure pregnancy prevention.
Supporting sourceClaims versus findings
Not established
Hormone suppression proves dependable contraception.
The cited short metabolic study did not measure contraceptive failure rates.
Check the evidenceCommon questions
Do stable fasting glucose values establish overall metabolic safety?
No. Other markers changed, and follow-up was short.
SourceSources
Metabolic findings in two prototype trials
PubChem chemical identity; checked October 1, 2026
Additional primary or official source
Sources checked 2026-10-01.
General education; not a personal treatment plan.